Congenital malformations in the city in the Metropolitan Region of Curitiba-PR
DOI:
https://doi.org/10.22421/1517-7130/es.2023v24.e916Keywords:
Congenital Abnormalities, Epidemiology Factors, Prenatal CareAbstract
Congenital malformations (CM) are structural/functional alterations that occur in the fetus, bringing socio-economic and emotional impact. Retrospective, documentary study with a quantitative approach, with the aim of identifying the relationship between risk factors and maternal epidemiological profile with the occurrence of CM. It was based on the analysis of 37 medical charts of pregnant women in a municipality in the metropolitan region of Curitiba-PR, between 2019 and 2021. The data revealed a profile: pregnant women between 18 and 36 years old, multiparous, obese, with comorbidities, without preconception evaluation. The most affected organic systems were cardiovascular, nervous or multiple systems. An increased risk of fetal malformations was identified in women over 25 years old, obese, who used alcohol or tobacco. Although a single cause of CM in that period and place has not been identified, an association was established between maternal epidemiological factors and characteristics of fetal malformations, highlighting the need for preconception health education.
References
Bateman BT, Huybrechts KF, Fischer MA, Seely EW, Ecker JL, Oberg AS, et al. Chronic hypertension in pregnancy and the risk of congenital malformations: a cohort study. American Journal of Obstetrics and Gynecology. 2015 Mar;212(3):337.e1–14.doi: 10.1016/j.ajog.2014.09.031.
Brandão I, Martins MJ, Monteiro R. Metabolically Healthy Obesity—Heterogeneity in Definitions and Unconventional Factors. Metabolites. 2020;10(2):48.doi:10.3390/metabo10020048
Castro INA, Batista EEV, Costa IL, Cunha DSC, Prates EKL, Vanetti AP et al. The use of isotretinoin in pregnant women and its effect on embryonic development. Brazilian Journal of Surgery and Clinical Research -BJSCR BJSCR [Internet]. 2020;30(2):2317–4404. Available from: https://www.mastereditora.com.br/periodico/20200409_102433.pdf
Chagas MHC, Flores H, Campos FACS, Santana RA, Lins ECB. Teratogenia da vitamina A. Revista Brasileira de Saúde Materno Infantil. 2003 Sep 1;3:247–52. doi: 10.1590/S1519-38292003000300003
Cristovam MA, Dallago RT, Fiori CMMC, Sandrini F, Rover MMS, Cristovam MAS, et al. Frequency of congenital anomalies in a Neonatal Intensive Care Unit in Brazil of congenital anomalies in a Neonatal Intensive Care Unit in Brazil. Residência Pediátrica. 2019;9(2):132–7. Available from:
Eriksen NB, Damm P, Mathiesen ER, Ringholm L. The prevalence of congenital malformations is still higher in pregnant women with pregestational diabetes despite near-normal HbA1c: a literature review. The Journal of Maternal-Fetal & Neonatal Medicine. 2017;32(8):1225–9.doi: 10.1080/14767058.2017.1402880.
Fontoura FC, Cardoso MVLML, Rodrigues SE, Almeida PC, Carvalho LB. Anxiety of mothers of newborns with congenital malformations in the pre- and postnatal periods. Revista Latino-Americana de Enfermagem. 2014 [cited 2021 Mar 13];23(4):907–21. https://doi.org/10.1590/1518-8345.2482.3080
Forrester MB, Merz RD. Risk of Selected Birth Defects with Prenatal Illicit Drug Use, Hawaii, 1986–2002. Journal of Toxicology and Environmental Health, Part A. 2006;70(1):7–18.doi: 10.1080/15287390600748799.
Frederiksen LE, Ernst A, Brix N, Braskhøj Lauridsen LL, Roos L, Ramlau-Hansen CH, et al. Risk of Adverse Pregnancy Outcomes at Advanced Maternal Age. Obstetrics & Gynecology [Internet]. 2018 Mar;131(3):457–63. Available from: https://journals.lww.com/greenjournal/Abstract/2018/03000/Risk_of_Adverse_Pregnancy_Outcomes_at_Advanced.7.aspx
Goetzinger KR, Shanks AL, Odibo AO, Macones GA, Cahill AG. Advanced Maternal Age and the Risk of Major Congenital Anomalies. American Journal of Perinatology.
;34(03):217–22. doi:10.1055/s-0036-1585410
Health MC for WM. Our New Website, June 2018 [Internet]. MGH Center for Women’s Mental Health. 2018 [cited 2022 Nov 13]. Available from: https://womensmentalhealth.org/posts/introducing_new_website_2018/
Khoshnood B, Greenlees R, Loane M, Dolk H. Paper 2: EUROCAT public health indicators for congenital anomalies in Europe. Birth Defects Research Part A: Clinical and Molecular Teratology. 2011 Mar;91(S1):S16–22.doi:10.1002/bdra.20776
Linha Guia-Atenção Materno Infantil Volume I Gestação [Internet]. Curitiba: SESA; 2022. Available from: https://www.saude.pr.gov.br/sites/default/arquivos_restritos/files/documento/2022-03/linha_guia_mi-_gestacao_8a_ed_em_28.03.22.pdf
Linhares AO, Cesar JA. Suplementação com ácido fólico entre gestantes no extremo Sul do Brasil: prevalência e fatores associados. Ciência & Saúde Coletiva [Internet]. 2017 Feb [cited 2020 Nov 4];22(2):535–42. Available from: https://www.scielosp.org/pdf/csc/2017.v22n2/535-542/pt
Lucena EES, Lima NA, Silva CF, Santos M, Fernandes T. Perfil Epidemiológico das Malformações Congênitas em Recém-Nascidos no Estado do Rio Grande do Norte no Período de 2004 a 2011. Revista Brasileira de Ciências da Saúde. 2018;22(1):45–50.doi:10.4034/RBCS.2018.22.01.06
Madi SRC, Garcia RMR, Souza VC, Rombaldi RL, Araújo BF, Madi JM. Effect of Obesity on Gestational and Perinatal Outcomes. Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics. 2017;39(07):330–6. doi: 10.1055/s-0037-1603826
Martínez-Frías ML, Bermejo E, Rodríguez-Pinilla E, Frías JL. Risk for congenital anomalies associated with different sporadic and daily doses of alcohol consumption during pregnancy: a case-control study. Birth Defects Research Part A, Clinical and Molecular Teratology [Internet]. 2004 Apr 1 [cited 2020 Mar 28];70(4):194–200.doi: 10.1002/bdra.20017
Mendes EV. O lado oculto de uma pandemia: a terceira onda da Covid-19. Coleção Covid-19 - Profissionais Saúde e Cuid Primários | 4 [Internet]. 2021;329–46. Available from: https://www.conass.org.br/biblioteca/volume-4-profissionais-de-saude-e-cuidados-primarios/
Mendes IC, Jesuino RSA, Pinheiro DS, Rebelo ACS. Congenital anomalies and its main avoidable causes: a review. Revista Médica de Minas Gerais. 2018;28. doi:10.5935/2238-3182.20180011
Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Vigilância em saúde no Brasil 2003|2019: da criação da Secretaria de Vigilância em Saúde aos dias atuais. Bol Epidemiol [Internet]. 2019 set [24 novembro 2022]; 50(n.esp.):1-154. Available from: http://www.saude.gov.br/ boletins-epidemiologicos.
Oliveira SM, López ML. Panorama epidemiológico de malformações congênitas no Brasil (2013-2017). Revista Saúde Multidisciplinar [Internet]. 2020 Nov 12 [cited 2022 Nov 13];8(2). Available from: http://revistas.famp.edu.br/revistasaudemultidisciplinar/article/view/121
Parnell AS, Correa A, Reece EA. Pre-pregnancy Obesity as a Modifier of Gestational Diabetes and Birth Defects Associations: A Systematic Review. Maternal and Child Health Journal. 2017;21(5):1105–20.doi:10.1007/s10995-016-2209-4
Persson M, Cnattingius S, Villamor E, Söderling J, Pasternak B, Stephansson O, et al. Risk of major congenital malformations in relation to maternal overweight and obesity severity: cohort study of 1.2 million singletons. BMJ. 2017 Jun 14;357. doi:10.1136/bmj.j2563
Pinheiro VP, Nunes CP. Manejo terapêutico no hipotireoidismo e gestação. Revista de Medicina de Família e Saúde Mental [Internet]. 2019 May 6 [cited 2022 Nov 24];1(1). Available from: https://www.unifeso.edu.br/revista/index.php/medicinafamiliasaudemental/article/view/1623/650
Rocha RS, Bezerra SC, Lima JWO, Costa FS. Consumo de medicamentos, álcool e fumo na gestação e avaliação dos riscos teratogênicos. Revista Gaúcha de Enfermagem. 2013 Jun [cited 2022 Jan 17];34(2):37–45. doi: 10.1590/S1983-14472013000200005
Roelands J, Jamison MG, Lyerly AD, James AH. Consequences of Smoking during Pregnancy on Maternal Health. Journal of Women's Health. 2009;18(6):867–72.doi: 10.1089/jwh.2008.1024.
Silva VC, Pires RCR, Cantanhede AM. Tendências recentes dos óbitos fetais por malformações congênitas: um estudo descritivo. Revista Eletrônica de Comunicação, Informação e Inovação em Saúde [Internet]. 2019 Dec 20 [cited 2022 Feb 2];13(4). Available from: https://www.reciis.icict.fiocruz.br/index.php/reciis/article/view/1545/2313
Vigitel Brasil 2020 - Vigilância de fatores de risco e proteção para doenças crônicas por inquérito telefônico — Português (Brasil) [Internet]. www.gov.br. 2020. Available from: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/publicacoes-svs/vigitel/relatorio-vigitel-2020-original.pdf/view
World Birth Defects Day- BDD [Internet]. World Birth Defects Day. United States, 2021. Available from: https://www.worldbirthdefectsday.org/>.
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